Practical Management of Thyroid Cancer by Ujjal K. Mallick & Clive Harmer

Author:Ujjal K. Mallick & Clive Harmer
Language: eng
Format: epub
ISBN: 9783319917252
Publisher: Springer International Publishing

Cytotoxic Chemotherapy

Cytotoxic chemotherapies provided low response rates (from 0 to 22% with the most frequently used agent, doxorubicin at a dose of 60 mg/m2 every 3–4 weeks) and toxicity was high [31]. Combination doxorubicin-cisplatin yielded similar low response rates to that of doxorubicin alone, but major toxicity was the added drawback. Very few trials have been reported on only limited series of patients with other cytotoxic agents. Paclitaxel appeared effective in a limited series of patients and the combination of gemcitabine and oxaliplatin appeared to be effective in some isolated patients [32, 33].

Treatment with interferon-α or interleukin-2, either alone or in combination with doxorubicin, or with somatostatin analogs failed to yield any tumor response. In some in vitro studies, retinoic acid analogs decreased the tumor growth rate and increased the expression of the sodium-iodine symporter. However, in clinical trials only minimal tumor effect and a small increase in 131I uptake were observed in only few patients [34].

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